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Quantum-Si Announces New Manuscript Demonstrating the Value of Single-molecule Protein Sequencing to Aid in Identifying New Cancer Treatment Strategies
In the pre-print titled “Heterologous expression of the human cohesin complex in Saccharomyces cerevisiae results in a dominant-negative phenotype”, the researchers expressed key human chromosome‑organizing proteins (called cohesins) in yeast cells. They hypothesized that the human cohesins were forming complexes and disrupting the activity of endogenous yeast cohesins. This matters for cancer drug development because problems with cohesin can drive genome instability in tumors, pointing to new ways to target cancer cells. Quantum-Si’s single‑molecule protein sequencing was critical to the study because it provided direct, unbiased data demonstrating that human and yeast cohesin proteins physically assemble into the same complexes—something conventional antibodies and assays could not fully resolve.
“We are excited to see the first manuscript published by international researchers,” said
A link to the bioRxiv pre-print can be found here.
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